Publications and Patents

2) A Free - Radical Acetonylation Method R Jaouhari , B Maillard , C Filliatre , and J J Villenave Synthesis , 1982 , 760

3) Synthèse d'aldehyde - fonctionnels par voie radicalaire C Filliatre , M Baratchart , J J Villenave et R Jaouhari Tetrahedron Letters , 1982 , 23 , 3487

4) Obtention d'aldehyde - fonctionnels au cours de la thermolyse du percarbonate de 0,0-t butyle et 0-vinyle en solution C Filliatre , J J Villenave , R Jaouhari et M Baratchart Bull Soc Chem Fr , 1982 , 11 , 352

5) Décomposition du percarbonate de 0,0-t butyle et 0-isopropenyle en solution dans les cyclanes R Jaouhari , B Maillard , C Filliatre et J J Villenave Tetrahedron , 1982 , 38 , 3137

6) Décomposition du percarbonate de 0,0-butyle et 0-isopropenyle en solution 11-partie : Acétonylation des cyclanones et oxacyclanes R Jaouhari , B Maillard , C Filliatre et J J Villenave Tetrahedron , 1982 , 39 , 1559

7) Acétonylation par voie radicalaire d'alcanes ramifiés : réactions de transfert de redicaux alkyles aux alcanes J J Villenave , R Jaouhari , C Filliatre et M Baratchart C C Acad Sc , 1982 , 292 (11) , 977

8) Déterminations cinétiques par microcalorimetrique différentielle - XVI - Décomposition du percarbonate de 0,0-t butyle et 0-isopropenyle en solution R Jaouhari , C Filliatre et J J Villenave Thermochim Acta 1983 , 60 , 341

9) Déterminations cinétique par microalorimetrique differentielle -XVII- Décomposition du percarbonate de 0,0-t butyle et 0-vinyle en solution R Jaouhari, C Filliatre et J J Villenave Thermochim Acta, 1983, 60, 353

10) Acétonylation radicalaire de la norbornanone-2 réaction avec la percarbonate isopropenyle J J Villenave, C Filliatre, R Jaouhari et M Baratchart Bull Soc Chim Belge, 1983, 92, 167

11) A convenient Synthesis of 1, 4-Diketones R Jaouhari, C Filliatre, B Maillard et J J Villenave Synth Comm, 1983, 13, 361

12) Analysis en RMN 13C de mélanges d'isomères: Acetonycyclanes et exacyclanes M Baratchart, C Filliatre, R Jaouhari, J J Villenave, B Barre et M Petraud Analysis, 1983, 11, 136

13) Dosage Spectrophotometrique de groupements carbonyles greffes sur des polymères J J Villenave, R Jaouhari, C Filliatre et M Baratchart Analysis, 1983, 11, 136

14) Functionalisation de polymères par action de percarbonates vinyliques, exemple: poly(exyethylenes) J J Villenave, C Filliatre, R Jaouhari et M Baratchart European Polymer J, 1983, 19, 575

15) Décomposition de percarbonates vinyliques en solution: comportement particulier dans les alkylbenzenes et les alcenes R Jaouhari, C Filliatre et J J Villenave C R Acad Sc, 1983, 296(11), 891

16) Réactions radicalaires de percarbonate de 0,0-t butyle et 0-isopropenyl: Acétonylations assistées par un co-amorceur R Jaouhari, C Filliatre et J J Villenave Canad J Chem, 1983, 61, 2295

17) The mass Spectra of Acetonylation Cyclanones R Jaouhari, C Filliatre, J J Villenave et G Bourgeois Org Mass Spectrum, 1983, 18(1), 149

18) Procède de synthèse d'isocyanates et dérivés d'isocyanates M C Bonnet, G Dawkins, R Jaouhari, I Tkatchenko et S Lecolier French Patent: No 84 19969 (28/12/1984) European Patent: No 85 402511 (17/12/1985)

19) Carbon-Carbon Coupling and Alkylation of Furan and Thiophen, involving C-H Bond Activation, with Ruthenium Catalysts in Alcohol R Jaouhari, P. Guenot and P.H. Dixneuf J.Chem.Soc., Chem Comm., 1986, 1255

20) Palladium Catalysed One Pot Carbonylation of Heterocyclic Compounds into their Esters, in presence of Mercury salts R. Jaouhari, P.H. Dixneuf and S. Lecolier Tetrahedron Lett., 1986, 27, 6315

21) A New Ruthenium Catalysed Reaction: Benzylation of Aromatic Hetriocyclic Compounds R. Jaouhari and P.H. Dixneuf Inorg. Chem. Acta, 1988, 145(2), 17

22) A Highly Selective Conversion of Bis [-2(Chloroethyl)] amine into the Corresponding Analogous Dialkylarsino R Jaouhari and P G Edwards Bull Soc Chem Belges, 1988, 3, 237

23) Synthesis of Bis [2-(dimethylarsino)] amine (DAEA) and its Complexion with Rh(1) and Pd(11) R Jaouhari and P G Edwards Recl Trav Chim Pays Bas, 1988, 107, 51

24) Synthesis of Characterization of Complexes of Nickel(11) with Platinum(11) with the new Bifunctional Aminophosphine Ligand Hn (CH CH CH Pme) P G Edwards and R Jaouhari Polyhedron, 1989, 8, 25

25) Synthesis of Difluoromethylenephosphonate Analogues of Glycerol-3-Phosphate.A Substrate for NADH Linkid G-3-Dehydrogenase R D Chambers, R Jaouhari and D O'Hagan J Chem Soc, Chem Comm, 1988, 1169

26) Fluorine in Enzyme Chemistry, Part 1. Synthesis of Difluoromethylenephosphonate Derivatives as Phosphates Mimics R D Chambers, R Jaouhari and D O'Hagan J Fluorine Chem, 1989, 44, 275

27) Fluorine in Enzyme Chemistry, Part 2. Preparation of Difluoromethelyenephosphonate Analogues of Glycolytic phosphates. Approaching and Isosteric and Ioselectronic Phosphate Mimic R D Chambers, R Jaouhari and D O'Hagan Tetrahedron, 1989, 45, 5101

28) General Study of the Benzylation of functionalized Aromatic Hydrocarbons Catalyzed by Ruthenium Complexes R Jaouhari Revue Roumaine de Chimie, 1989, 8, 1733

29) Chemoenzymetic , Enantiocomplementary , Total Asymetric Synthesis of Leukotrienes - B3 and B4 I C Coterill , G Dorman , K Faber , R Jaouhari , S M Roberts , F Scheinmann , J Spreitz , A G Sutherland , J A Winders and B J Wakefield J Chem Soc , Chem Comm , 1990 , 1661

30) Use of the Two Enantiomers of 7 , 7-Dimethylbicyclo[3.2.0.]-hept-2-en-6-one to Form the Two Optically Active Sythons in a Convergent Synthesis of Leukotriene - B4 I C Coterill , R Jaouhari , G Dorman , S M Robers , F Scheinmann and BJ Wakefield J Chem Soc , Perkin Trans 1 , 1991 , 2505

31) Improved Efficiency and Selectivity in Peptide Synthesis : Use of Triethylsilane as a Carbocation Scavenger in Deprotection of t-Butyle Esters and T-Butoxycarbonyl - Protected Sites A Mehta , R Jaouhari , T J Benson and K T Douglas Tetrahedron Lett , 1992 , 33 , 5441

32) Rational Design of Peptide- Based Inhibitors of Trypanothione Reductase as Potential Antitrypanosomal Drugs J Garforth , J H McKie , R Jaouhari , T J Benson , A H Fairlamb and K T Douglas Amino Acid , 1994 , 6 (3) , 295

33) Use of Transferred Nuclear Overhauser Effect Spectroscopy to Study a Novel Inhibitor of Yease Glutathione Reductase K T Embry , A Mehta , S J Carrington , R Jaouhari , J H McKie and K T Douglas European J Biochemistry , 1994 , 221 , 793

34) The First Protoberberine Alkaloid Analogue with in Vivo Animalarial Activity D L C McCall , J Alexander , J Barber , R Jaouhari , A Satoskar and R D Waigh BioMed . Chem . Lett . , 1994 , 4 , 1663

35) A New Ruthenium Catalysed Reaction . Benzylation of Functional Aromatic Compounds R Jaouhari Chemistry Lett ., 1994 , 10 , 1781

36) Improved Process for the Preparation of 2- Methyl - 3 - Trfluoromethylaniline : A Versatile Intermediate For Flunixin Preparation R . Jaouhari and P. Quinn Hterocycles , 1994 , 38 (10 ) , 2243

37) Novel Appraches Toward Ninhydrin Analogs R R Hark , D B Hauze , O Petrovskaia , M M Joullie , R Jaouhari and P . McComisky Tetrahedron Lett , 1994 , 35 (42 ) , 7719

38) Synthesis of Mixed Disulfide Potential Alternative Substrates for Trypanothione and Glutathione Reductases. T . Besheya , R Jaouhari , J H McKie , J Garforth and K T Douglas Amino Acids , 1995 , 9 (1 ) , 66

39) Inhibitors of Trypanathione Reductase as Potential Antitrypanosomal Drugs C Chan , H Yin , J Garforth , J H McKie , R Jaouhari , K T Douglas , A H Fairlamb and S L Croft . Biochem Soc Trans , (1995) , 1995 , 23 , 5115

40) Synthesis of Symmetric Disulfide as Potential Alternative Subtrates for Trypanothione Reductase and Glutathione Reductase : Part 1 R Jaouhari , T Besheya , J H McKie and K T Douglas . Amino Acids , (1995) , 9(4) , 327

41) Synthesis of Asymmetric Disulfide as Potential Alternative Substrates for Trypanothione Reductanse and Glutathione Reductanse : Part 2 R Jaouhari , T Besheya , J H McKie and K T Douglas . Amino Acids , (1995) , 9(4) , 343

42) The Role of Sulfoacetaldehyde Sulfo-Lyase in the Mineralisation of Isethionate by an Environmental Acinetobacter J E King, R Jaouhari and J P Quinn Microbiology, 1997, 143, 2339

43) A New Synthesis of Enantiopure Ifosfamide via Optically Active Phosphorus Thioacid R Jaouhari , P. Quinn, M A McKervey and B J Walker Subject to a British Patent , (1998)

44) An Altenative Stereospecific Synthesis of Enantiopure Ifosfamide : new Version of Stec's Reaction via Optically Active Thiophosphamide R Jaouhari , M A McKervey and B J Walker Subject to a British Patent , (1998)

45) Spontanious in situ oxidation of 2-Chloro-1 , 3 , 2-Oxazaphosphorine . A Versatile Intermediate for the Synthesis of Ifosfamide R Jaouhari , S Barr , M A McKervey and B J Walker Subject to a British Patent , (1998)

46) Resolution of t - Leucine via Oxazolone Ring Opening With Chiral Amine Nucleophiles R Jaouhari , M A McKarvey , and B J Walker Subject to a British Patent , (1998)

47) Phenothiazine Inhibitors of trypanothione reductase as Potential Antitrypanosomal and Antilesishmanial Drugs C Chan, H Yin, , J Garforth , J H McKie , R Jaouhari , P Speers, K T Douglas P J Rock, V Yardley, S L Croft and A H Fairlamb J. Med. Chem., 1998, 41, 2, 148

48) Synthesis and Enzymology of Modified N - Benzyloxycarbonyl - L - Cycteinylglycyl - 3 - dimethylaminopropilamide Disulfides as Alternative Substrates for Trypanothione Reductase from Trypanosoma cruzi - Part 3 C T Yuen , J Garforth , T Besheya , R Jaouhari , J H McKie , A H Fairlamb and K T Douglas Amino Acids , 1999, 17, 175

49) Synthesis and Enzymology of Amino - Protected Methionine Derivatives As Inhibitors for Trypanothione Reductase from Trypansoma cruzi - Part 4 C T Yuen , J Garforth , R Jaouhari , J H McKie , A H Fairlamb and K T Douglas Amino Acids , in Preparation

50) JJ Brunet, P Legars, Itkatchenko, S Lecolier Tet.Letters 29 N° 36 pp 4559-72 19888 Carbonylation of tertiary alkyl halides

51) C Bruneau, P H Dixneuf , S Lécolier Journal of molecular catalysis V 44 (1988) pp 175-178 Acétylène in catalysis: a one step synthesis of vinyl carbamates with Ruthenium catalysts

52) C Bruneau , M Neveux, P Dixneuf, S Lécolier Synlett Accounts and rapid communication in synthetic organic chemistry 1991 N° 1 p755-763 Ruthenium catalysed additions to alkynes and their use in acylation réactions

ABSTRACTS (SYMPOSIUM)

* Differential Recognition of Glutathione Reductase and Trypanothione Reductase J Garforth, T J Benson, J H McKie, R Jaouhari, A Borges, M Cunningham, A H Fairlamb and K T Douglas The Biochemical Society, 646th Meeting, University of Leeds (England), 1993 (March), 151

* Use of Transferred Nuclear Overhauser Spectroscopy to Study a Novel Inhibitor of Yease Glutathione Reductase K T Embry, A Mehta, S J Carrington, R Jaouhari, J H McKie and K T Douglas The Biochemical Society, 646th Meeting, Univesity of Leeds (England), 1993 (March), 150

* Rational Design of Peptide-Based Inhibitors of Trypanothione Reductase as Potential Antitrypanosomal Drugs J Garfoth, J H McKie and R Jaouhari 3rd International Congress on Amino Acids, Peptides and Analogues, Vienna (Austria), Amino Acids, 1993, 5(1), 139

The First Protoberberine Alkaloid Analogue with in Vivo Antimalarial Activity D L C McCall, R Jaouhari and R D Waigh Belgium Organic Synthesis Symposium, Namur (Belgium), July 1994, 109

* Bacterial Biotransformation studies of Bicyclic Arenes using Pseudomonas Putida D R Boyd, M R Groocock, D N Sharma, J F Malone and R Jaouhari Belgium Organic Synthesis Symposium, Namur (Belgium), July 1994, 120

* 2-Alkylcyclobbutanones: References Markers for the Detection of Lipid-Containing Foodstuffs D R Boyd, P Quinn, I Brannigan and R Jaouhari Agriculture & Food Symposium, The Queen University of Belast, June, 1994

Synthesis of Mixed Disulphide Potential Alternative Substrates for Trypanothione and Glutathione Reductase T Besheya, R Jaouhari, J H McKie, J Garforth and K T Douglas 4th International Meeting on Amino Acids, Vienna (Austria), 7-11th August 1995